Small-molecule inhibitor starting points learned from protein-protein interaction inhibitor structure
نویسندگان
چکیده
منابع مشابه
Small-molecule inhibitor starting points learned from protein–protein interaction inhibitor structure
MOTIVATION Protein-protein interactions (PPIs) are a promising, but challenging target for pharmaceutical intervention. One approach for addressing these difficult targets is the rational design of small-molecule inhibitors that mimic the chemical and physical properties of small clusters of key residues at the protein-protein interface. The identification of appropriate clusters of interface r...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2012
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bts305